| Cat. No. |
Product Name |
Information |
| PC-25571 |
OAT-4828 dihydrochloride
USP7 inhibitor
|
OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system). |
| PC-25550 |
USP19-IN-1
USP19 inhibitor
|
USP19-IN-1 (Example 124) is a potent, selective USP19 inhibitor with IC50 of <0.5 uM, high selective against a panel of 24 USPs and 19 other DUBs. |
| PC-25142 |
USP10 inhibitor LY-2
USP10 inhibitor
|
USP10 inhibitor LY-2 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with SPR binding KD of 365 nM and IC50 of 10.87 uM. |
| PC-24885 |
Hyperoside
USP18 inhibitor
|
Hyperoside is a naturally occurring flavonol glycoside with anti-colitis and anticancer potential, also is a USP18 inhibitor that directly targets the USP18 IBB1 domain (BLI KD=7.04 uM), hyperoside inhibits PRRSV proliferation via the TLR4/NF-kappaB and p62-Nrf2-Keap1 signaling pathways. |
| PC-24793 |
STIRUR 41
USP7 inhibitor
|
STIRUR 41 (STIRUR-41, STIR UR 41) is a small molecule USP-7 inhibitor with IC50 of 2.77 uM in HTLA-230 cells, STIRUR 41 (5-10 uM) STIRUR 41 induces a remarkable decrease in USP-7 protein levels in HTLA-230 cells. |
| PC-24713 |
USP24-i-101
USP24 inhibitor
|
USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively. |
| PC-24549 |
TNG-6132
USP1 inhibitor
|
TNG-6132 is a potent, selective, reversible, allosteric and orally bioavailable USP1 inhibitor with pIC50 of 7.9 (USP1-UAF1 complex), and pIC50 of 7.6 in cellular viability assay with MDA-MB-436 cells. |
| PC-24536 |
NK036
USP30 inhibitor
|
NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively. |
| PC-24507 |
K-552
USP47 inhibitor
|
K-552 is a specific small molecule inhibitor of USP47 with Kd of 12.3 uM (cUSP47CD), shows more specific interactions with cUSP47CD than hUSP7CD. |
| PC-24352 |
USP7 activator MS-8
USP7 activator
|
USP7 activator MS-8 is a selective small molecule activator of ubiquitin-specific protease 7 (USP7), does not activate USP47 and shows selectivity against other DUBs. |
| PC-24052 |
USP1 inhibitor 38-P2
USP1 inhibitor
|
USP1 inhibitor 38-P2 is a potent, selective, reversible, and noncompetitive ubiquitin-specific protease 1 (USP1) inhibitor with IC50 of 3.8 nM (USP1-UAF1). |
| PC-23952 |
U4-I05
USP4 inhibitor
|
U4-I05 is a specific small molecule USP4 inhibitor (KD=239 nM) that inhibits USP4 deubiquitinating enzyme activity, inhibits stemness characteristics in CRC cells. |
