Zerumbone

Chemical Structure : Zerumbone

CAS No.: 471-05-6

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货号: PC-22863Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

Zerumbone is a natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet with anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity, binds to transgelin (TAGLN) and reduces the retention of USP1 in the cytoplasm and the degradation of ZEB1 ubiquitination.
Zerumbone inhibits proliferation of a wide variety of tumor cells, on the activity of Hsp90.
Zerumbone enhanced the ATPase activity of cyanobacterial Hsp90 (Hsp90SE), yeast Hsp90, and human Hsp90α.
Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha.

物理化学性质&存储条件

分子量	218.34
分子式	C15H22O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienone

参考文献

1. Yinan Li, et al. Cell Biosci. 2023 May 6;13(1):80.

2. Nakamoto H, et al. Biochem J. 2018 Aug 16;475(15):2559-2576.

3. Singh SP, et al. Sci Rep. 2018 Mar 6;8(1):4090.

Zerumbone

生物&药学活性

物理化学性质&存储条件

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Zerumbone

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