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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-Vialinin A
Vialinin A

Chemical Structure : Vialinin A

CAS No.: 858134-23-3

Vialinin A (Terrestrin A)

货号: PC-22183Not For Human Use, Lab Use Only.

Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties, inhibits the peptidase activity of USP5/IsoT with IC50 of 5.9 uM, also inhibits the enzymatic activities of USP4 with IC50 of 1.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties, inhibits the peptidase activity of USP5/IsoT with IC50 of 5.9 uM, also inhibits the enzymatic activities of USP4 with IC50 of 1.5 uM.
Vialinin A inhibiting the release of TNF-α (IC50= 0.09 nM) from rat basophilic leukemia cells (RBL-2H3 mast cells).
Vialinin A shows no significant inhibition was observed in terms of the UCH-L3, USP2, and USP8 activities.
Vialinin A dampened Th17 differentiation with high expressed USP4.

物理化学性质&存储条件

分子量 562.57
分子式 C34H26O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,4'',5',6'-tetrahydroxy-[1,1':4',1''-terphenyl]-2',3'-diyl bis(2-phenylacetate)

参考文献

1. Yang J, et al. J Immunol. 2015 May 1;194(9):4094-7.

2. Zhang J, et al. Mol Med Rep. 2019 Aug;20(2):1429-1435.

3. Ning F, et al. Pharmacol Res. 2020 Jul;157:104557.

4. Okada K, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4328-31.

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