Compound 7695-0983

Chemical Structure : Compound 7695-0983

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货号: PC-22320Not For Human Use, Lab Use Only.

Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy.
Compound 7695-0983 binds to the active pocket of FAT10.
Compound 7695-0983 can enhance the sensitivity of HCC-SR cells to sorafenib.
Compound 7695-0983 combined with sorafenib could inhibit FAT10 to inhibit NEDD4-PTEN/AKT axis-mediated autophagy to increase sorafenib-induced apoptosis.
HLA-F locus-adjacent transcript 10 (FAT10) is a specific ubiquitin-like protein, which can directly mediate the ubiquitin-independent proteasomal degradation of substrates.

物理化学性质&存储条件

分子量	349.39
分子式	C20H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 4-(3-hydroxyphenyl)-2-methyl-1,4-dihydropyrimido [1,2-a] benzimidazole-3-carboxylate

参考文献

1. Wenming Zhang, et al. Am J Cancer Res. 2024 Apr 15;14(4):1523-1544.