CT1113 | USP28 inhibitor | Probechem Biochemicals

Chemical Structure : CT1113

加入收藏

CT1113 (CT-1113)

货号: PC-22261Not For Human Use, Lab Use Only.

CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively.
CT1113 displays no activity against other deubiquitinases and SENP1 at 1 uM.
CT1113 strongly destabilize NOTCH1 and inhibit the growth of T-ALL cells.
Inhibition of USP28 by CT1113 resulted in increased ubiquitination of the ICN1 protein in T-ALL cell lines (Jurkat and MOLT-4).
CT1113 induces apoptosis in T-ALL cells with or without mutant NOTCH1.
CT1113 significantly inhibited leukaemia progression in Jurkat xenograft, inhibits NOTCH1-driven T-cell leucaemogenesis.
CT1113 demonstrated anti-leukaemia efficacy in a NOTCH1-independent patient-derived T-ALL xenograft.

物理化学性质&存储条件

分子量	463.60
分子式	C25H29N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3R)-7-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methyl-3-(methylamino)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Jin Peng, et al. Signal Transduct Target Ther. 2022 Dec 8;7(1):393.

2. Jieyu Xu, et al. Br J Haematol. 2024 Apr 29. doi: 10.1111/bjh.19492.

CT1113 (CT-1113)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CT1113 (CT-1113)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.