| Cat. No. |
Product Name |
Information |
| PC-42758 |
MK-0752
γ-secretase inhibitor
|
MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling. |
| PC-45889 |
BMS-299897
γ-secretase inhibitor
|
BMS-299897 is a potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM. |
| PC-42053 |
Semagacestat
γ-secretase inhibitor
|
Semagacestat (LY-450139) is a potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively. |
| PC-45860 |
LY-411575
γ-secretase inhibitor
|
LY-411575 is a potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines. |
| PC-45626 |
L-685458
γ-secretase inhibitor
|
L-685458 (L-685,458) is a potent inhibitor of amyloid β-protein precursor gamma-secretase activity (IC50=14 nM). |
| PC-26917 |
LY3056480
γ-Secretase inhibitor
|
LY3056480 is a potent gamma secretase (γ-secretase) inhibitor (GSI), upregulates ATOH1 expression in human intestinal epithelial cell line LS174T with IC50 of 17.3 nM, inhibits Notch signalling and induces hair cell formation. |
| PC-24101 |
RO-02
γ‐secretase modulator
|
RO-02 (RO5434400) is a small molecule γ-secretase modulator (GSM), lowers Aβ42 species in HEK293 cells stably expressing the APPsw mutant (HEK293/sw) with IC50 of 12 nM, lowers Aβ40 and Aβ42 generation. |
| PC-24100 |
RO5254601
γ‐secretase modulator
|
RO5254601 is a novel indole-type γ-secretase modulator (GSM) with IC50 (Aβ42) of 380 nM in HEK293/sw cells, increases the production of Aβ38. |
| PC-24099 |
RO7019009
γ‐secretase modulator
|
RO7019009 is a small molecule γ‐secretase modulator, efficiently reduces the levels of Aβ42 (IC50=14 nM) and Aβ40 secreted by HEK293/sw cell, effectively lowers Aβ43 of all Aβ43‐generating mutants. |
| PC-22499 |
GSM-776890
γ-secretase modulator
|
UCSD-776890 (UCSD-776890) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 4.2 nM, Aβ40 IC50 of 80 nM, also shows EC50 of 18 nM for potentiating Aβ38 secretion. |
| PC-22498 |
NGP-555
γ-secretase modulator
|
NGP-555 (NGP555) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 10 nM. |
| PC-22497 |
E-2212
γ-secretase modulator
|
E-2212 is a potent, selective γ-secretase modulator with Aβ42 IC50 of 7 nM. |
