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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-BMS-433796
BMS-433796

Chemical Structure : BMS-433796

CAS No.: 935525-13-6

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BMS-433796 (BMS 433796)

货号: PC-45890Not For Human Use, Lab Use Only.

BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.
    BMS-433796 exhibits Abeta lowering activity in a transgenic mouse model of Alzheimer's disease with acceptable pharmacodynamic and pharmacokinetic profile..

    物理化学性质&存储条件

    分子量 430.4
    分子式 C21H20F2N4O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    DMSO: 10 mM
    Chemical Name/SMILES

    Benzeneacetamide, N-[(1S)-2-[[(5S)-4,5-dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-

    参考文献

    1. Prasad CV, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11.

    2. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.

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