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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-L-685458
L-685458

Chemical Structure : L-685458

CAS No.: 292632-98-5

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L-685458 (L-685,458;L685458;L 685458)

货号: PC-45626Not For Human Use, Lab Use Only.

L-685458 (L-685,458) is a potent inhibitor of amyloid β-protein precursor gamma-secretase activity (IC50=14 nM).

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5 mg ￥3880 In stock
10 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

L-685458 (L-685,458) is a potent inhibitor of amyloid β-protein precursor gamma-secretase activity (IC50=14 nM).
L-685458 shows similar potency for inhibition of A beta(42) and A beta(40) peptides.

物理化学性质&存储条件

分子量 672.8534
分子式 C39H52N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-

参考文献

1. Shearman MS, et al. Biochemistry. 2000 Aug 1;39(30):8698-704.

2. Pozdnyakov N, et al. J Biol Chem. 2013 Apr 5;288(14):9710-20.

3. Liu F, et al. Eur J Neurosci. 2013 May;37(10):1714-25.

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