RO5254601

Chemical Structure : RO5254601

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货号: PC-24100Not For Human Use, Lab Use Only.

RO5254601 is a novel indole-type γ-secretase modulator (GSM) with IC50 (Aβ42) of 380 nM in HEK293/sw cells, increases the production of Aβ38.

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生物&药学活性

RO5254601 is a novel indole-type γ-secretase modulator (GSM) with IC50 (Aβ42) of 380 nM in HEK293/sw cells, increases the production of Aβ38.
RO5254601 also increased Aβ37, which is normally less abundant than Aβ38.
RO5254601 does not impair Notch1 cleavage.
RO5254601 reduces Aβ42 in PS1 L166P KI MEF cells.

物理化学性质&存储条件

分子量	397.43
分子式	C22H21F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1-acetylpiperidin-3-yl)-N-(3,5-difluorophenyl)-1H-indole-2-carboxamide

参考文献

1. Trambauer J, et al. Alzheimers Res Ther. 2025 Feb 19;17(1):49.

2. Trambauer J, et al. EMBO Rep. 2020 Jan 7;21(1):e47996.

RO5254601

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物理化学性质&存储条件

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RO5254601

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