Semagacestat |CAS:425386-60-3 Probechem Biochemicals

Chemical Structure : Semagacestat

CAS No.: 425386-60-3

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Semagacestat (LY450139;LY-450139)

货号: PC-42053Not For Human Use, Lab Use Only.

Semagacestat (LY-450139) is a potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively.

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1 mg (Free Sample)	￥180	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Semagacestat (LY-450139) is a potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively.
Semagacestat (LY-450139) reduces the secretion of Aβ42, Aβ40, and Aβ38 in cells and increases β-CTF in cell lysates, also inhibits Notch signaling with IC50 of 14.1 nM.
Semagacestat (LY-450139) increases intracellular byproduct peptides, produced along with Aβ through serial γ-cleavage of βAPP, as well as intracellular long Aβ species, in cell-based and in vivo studies of AD model mice; a pseudo-inhibitor of γ-secretase.

物理化学性质&存储条件

分子量	361.4354
分子式	C19H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanamide, 2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-, (2S)-

参考文献

1. Lanz TA, et al. J Pharmacol Exp Ther. 2006 Nov;319(2):924-33.

2. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.

3. Elvang AB, et al. J Neurochem. 2009 Sep;110(5):1377-87.

4. Tagami S, et al. Cell Rep. 2017 Oct 3;21(1):259-273.

Semagacestat (LY450139;LY-450139)

生物&药学活性

物理化学性质&存储条件

参考文献

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Semagacestat (LY450139;LY-450139)

生物&药学活性

物理化学性质&存储条件

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