LY-411575 | γ-secretase inhibitor | Probechem Biochemicals

Chemical Structure : LY-411575

CAS No.: 209984-57-6

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LY-411575 (LY411575, LY 411575)

货号: PC-45860Not For Human Use, Lab Use Only.

LY-411575 is a potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines.

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5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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生物&药学活性

LY-411575 is a potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines.
LY-411575 dose dependently reduces Aβ(1-40) and Aβ(1-42) in the brain, CSF, and plasma of Tg2576 mice.
LY-411575 reduces cortical Abeta(40) in young transgenic CRND8 mice with ED50 of 0.6 mg/kg, and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg).

物理化学性质&存储条件

分子量	479.4753
分子式	C26H23F2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-.alpha.-hydroxy-, (.alpha.S)-

参考文献

1. Lanz TA, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):49-55.

2. Best JD, et al. J Pharmacol Exp Ther. 2005 May;313(2):902-8.

3. Hyde LA, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43.

LY-411575 (LY411575, LY 411575)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY-411575 (LY411575, LY 411575)

生物&药学活性

物理化学性质&存储条件

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