RO-02 | γ‐secretase modulator | Probechem Biochemicals

Chemical Structure : RO-02

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RO-02 (RO5434400)

货号: PC-24101Not For Human Use, Lab Use Only.

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生物&药学活性

RO-02 (RO5434400) is a small molecule γ-secretase modulator (GSM), lowers Aβ42 species in HEK293 cells stably expressing the APPsw mutant (HEK293/sw) with IC50 of 12 nM, lowers Aβ40 and Aβ42 generation.
RO-02 increases the short species Aβ38, and also inhibits Aβ40 formation.
RO-02 exhibits potent and preferential Aβ42-lowering activity of RO-02 was confirmed in rat primary cortical neurons (IC50 (Aβ42) =13 nM).
RO-02 modulates the generation of Aβ species by γ-secretase from the recombinant APP substrate C100-His6 as expected (IC50 (Aβ42) = 0.5 uM) and without affecting the levels of total Aβ and total AICD in cell-free in vitro assays.

物理化学性质&存储条件

分子量	463.97
分子式	C25H26ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-(4-chlorobenzyl)-2-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)amino)pyrimidin-4-yl)propan-2-ol

参考文献

1. Ebke A, et al. J Biol Chem. 2011;286:37181–6.

2. Trambauer J, et al. EMBO Rep. 2020 Jan 7;21(1):e47996.

RO-02 (RO5434400)

生物&药学活性

物理化学性质&存储条件

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RO-02 (RO5434400)

生物&药学活性

物理化学性质&存储条件

参考文献

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