| Cat. No. |
Product Name |
Information |
| PC-62912 |
BMS-698861
γ-secretase modulator
|
BMS-698861 is a potent γ-secretase modulator (GSM) that decreases levels of all the peptides, Aβ1-40, Aβ1-42, Aβ1-38, Aβ1-37 and Aβ1-x, results in APP-CTFβ and APP-CTFα accumulation in brain. |
| PC-62911 |
BMS-869780
γ-secretase modulator
|
BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates. |
| PC-62793 |
SCH 900229
γ-secretase inhibitor
|
SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM). |
| PC-61830 |
PF-06648671
γ-secretase modulator
|
PF-06648671 (PF6648671) is a potent, selective and oral γ-secretase modulator (GSM), reduces Aβ42 (IC50=9.8 nM) and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. |
| PC-61757 |
BMS-986115
γ-secretase inhibitor, Notch inhibitor
|
BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity. |
| PC-60978 |
AMG2008827
γ-secretase inhibitor
|
A potent, selective γ-secretase inhibitor that significantly reduces the right ventricular systolic pressure and right heart hypertrophy in hypoxia/SU5416 (SUHx) rats.. |
| PC-70070 |
MRK-003
γ-secretase inhibitor
|
MRK-003 (MRK003) is a potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells. |
| PC-45867 |
BMS-708163
γ-secretase inhibitor
|
Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM. |
| PC-42071 |
E-2012
γ-secretase modulator
|
E-2012 (E2012) is a potent, second-generation γ-secretase modulator that decreases Aβ(1-39), Aβ(1-40) and A(1-42), and increases Aβ(1-37). |
| PC-45890 |
BMS-433796
γ-secretase inhibitor
|
BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM. |
| PC-42758 |
MK-0752
γ-secretase inhibitor
|
MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling. |
| PC-45889 |
BMS-299897
γ-secretase inhibitor
|
BMS-299897 is a potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM. |
