SCH 900229 |CAS:1100361-36-1 Probechem Biochemicals

Chemical Structure : SCH 900229

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SCH 900229 (SCH900229)

货号: PC-62793Not For Human Use, Lab Use Only.

SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM).

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生物&药学活性

SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM).
SCH 900229 demonstrates excellent lowering of Aβ in preclinical animal models.

物理化学性质&存储条件

分子量	506.96
分子式	C21H21ClF2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,4aS,10bS)-10b-[(4-Chlorophenyl)sulfonyl]-7,10-difluoro-1,4a,5,10b-tetrahydro-4-[2-(methylsulfonyl)ethyl]-2H,4H-pyrano[3,4-c][1]benzopyran

参考文献

1. Wu WL, et al. ACS Med Chem Lett. 2012 Apr 9;3(11):892-6.

2. Wu WL, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841.

3. Wu WL, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841.

SCH 900229 (SCH900229)

生物&药学活性

物理化学性质&存储条件

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SCH 900229 (SCH900229)

生物&药学活性

物理化学性质&存储条件

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