MRK-560 |CAS:677772-84-8 Probechem Biochemicals

Chemical Structure : MRK-560

CAS No.: 677772-84-8

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MRK-560 (MRK560)

货号: PC-62921Not For Human Use, Lab Use Only.

MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.
MRK-560 inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with IC50 of 0.65 nM.
MRK-560 reduces levels of Aβ in the brain and cerebrospinal fluid (CSF) in rats with ED50 of 6 and 10 mg/kg.

物理化学性质&存储条件

分子量	517.91
分子式	C19H17ClF5NO4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide

参考文献

1. Best JD, et al. J Pharmacol Exp Ther. 2006 May;317(2):786-90.

2. Best JD, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8.

3. Wang FH, et al. Eur J Neurosci. 2012 Nov;36(9):3165-72.

MRK-560 (MRK560)

生物&药学活性

物理化学性质&存储条件

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MRK-560 (MRK560)

生物&药学活性

物理化学性质&存储条件

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