BMS-869780 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : BMS-869780

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BMS-869780 (BMS869780)

货号: PC-62911Not For Human Use, Lab Use Only.

BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.

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100 mg		Get quote

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生物&药学活性

BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.
BMS-869780 does not inhibit Notch processing by γ-secretase and loweres brain Aβ1-42 without evidence of Notch-related side effects in rats.
BMS-869780 shows synergistic inhibition of Aβ combined with GSM-2.

物理化学性质&存储条件

分子量	452.918
分子式	C23H22ClFN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(9S)-N-[4-(4-Chloro-1H-imidazol-1-yl)-3-methoxyphenyl]-9-(4-fluorophenyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-2-amine

参考文献

1. Toyn JH, et al. Int J Alzheimers Dis. 2014;2014:431858.

2. Robertson AS, et al. Eur J Pharmacol. 2017 Oct 5;812:104-112.

BMS-869780 (BMS869780)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-869780 (BMS869780)

生物&药学活性

物理化学性质&存储条件

参考文献

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