BMS-869780 |CAS:1235493-78-3 Probechem Biochemicals

Chemical Structure : BMS-869780

加入收藏

BMS-869780 (BMS869780)

货号: PC-62911Not For Human Use, Lab Use Only.

BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.
BMS-869780 does not inhibit Notch processing by γ-secretase and loweres brain Aβ1-42 without evidence of Notch-related side effects in rats.
BMS-869780 shows synergistic inhibition of Aβ combined with GSM-2.

物理化学性质&存储条件

分子量	452.918
分子式	C23H22ClFN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(9S)-N-[4-(4-Chloro-1H-imidazol-1-yl)-3-methoxyphenyl]-9-(4-fluorophenyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-2-amine

参考文献

1. Toyn JH, et al. Int J Alzheimers Dis. 2014;2014:431858.

2. Robertson AS, et al. Eur J Pharmacol. 2017 Oct 5;812:104-112.

BMS-869780 (BMS869780)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BMS-869780 (BMS869780)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.