AZ 4800 |CAS:1226886-78-7 Probechem Biochemicals

Chemical Structure : AZ 4800

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AZ 4800 (AZ4800)

货号: PC-62920Not For Human Use, Lab Use Only.

AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38..

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生物&药学活性

AZ 4800 is a potent γ-secretase modulator that reduces Aβ40 and Aβ42 levels in HEK/APPswe cells with IC50 of 26 nM and 60 nM, also decreases Aβ39, whereas increases both Aβ37 and Aβ38.

物理化学性质&存储条件

分子量	435.528
分子式	C24H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(cyclopentyloxymethyl)-N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-amine

参考文献

1. Borgegard T, et al. J Biol Chem. 2012 Apr 6;287(15):11810-9.

2. Strömberg K, et al. FEBS J. 2015 Jan;282(1):65-73.

AZ 4800 (AZ4800)

生物&药学活性

物理化学性质&存储条件

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AZ 4800 (AZ4800)

生物&药学活性

物理化学性质&存储条件

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