GSM-2 |CAS:956465-56-8 Probechem Biochemicals

Chemical Structure : GSM-2

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GSM-2 (GSM2)

货号: PC-62913Not For Human Use, Lab Use Only.

GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.

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生物&药学活性

GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.
GSM-2 significantly ameliorates memory deficits in Tg2576 mice and does not affect normal cognition in wild-type mice.

物理化学性质&存储条件

分子量	467.5
分子式	C23H31F6NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2S,4R)-1-((R)-1,1,1-trifluoro-7-methyloctan-4-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

参考文献

1. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.

2. Robertson AS, et al. Eur J Pharmacol. 2017 Oct 5;812:104-112.

3. Mitani Y, et al. J Neurochem. 2013 May;125(3):465-72.

GSM-2 (GSM2)

生物&药学活性

物理化学性质&存储条件

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GSM-2 (GSM2)

生物&药学活性

物理化学性质&存储条件

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