BMS-986115 |CAS:1584647-27-7 Probechem Biochemicals

Chemical Structure : BMS-986115

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BMS-986115 (BMS986115)

货号: PC-61757Not For Human Use, Lab Use Only.

BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.

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5 mg		Get quote
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25 mg		Get quote

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生物&药学活性

BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.
BMS-986115 binds to gamma-secretase and blocks the proteolytic cleavage and release of the Notch intracellular domain (NICD), which would normally follow ligand binding to the extracellular domain of the Notch receptor.
BMS-986115 induces apoptosis and inhibits growth of tumor cells that overexpress Notch.

物理化学性质&存储条件

分子量	574.495
分子式	C26H25F7N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S)-N1-[(3S)-5-(3-Fluorophenyl)-2,3-dihydro-9-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide

参考文献

1. Aung KL,et al. Invest New Drugs. 2018 Dec;36(6):1026-1036.

BMS-986115 (BMS986115)

生物&药学活性

物理化学性质&存储条件

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BMS-986115 (BMS986115)

生物&药学活性

物理化学性质&存储条件

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