BMS-708163 |CAS:1146699-66-2 Probechem Biochemicals

Chemical Structure : BMS-708163

CAS No.: 1146699-66-2

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BMS-708163 (Avagacestat, BMS708163)

货号: PC-45867Not For Human Use, Lab Use Only.

Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.

规格	价格	库存
1 mg (Free Sample)	￥180	In stock
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
Avagacestat (BMS-708163) demonstrates 193-fold selectivity against Notch.
Avagacestat (BMS-708163) significantly reduced Aβ40 levels for sustained periods in brain, plasma, and cerebrospinal fluid in rats and dogs.

物理化学性质&存储条件

分子量	520.885
分子式	C20H17ClF4N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)-

参考文献

1. Gillman KW, et al. ACS Med Chem Lett. 2010 Mar 22;1(3):120-4.

2. Albright CF, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):686-95.

3. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.

BMS-708163 (Avagacestat, BMS708163)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BMS-708163 (Avagacestat, BMS708163)

生物&药学活性

物理化学性质&存储条件

参考文献

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