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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-LY3056480
LY3056480

Chemical Structure : LY3056480

CAS No.: 2064292-78-8

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LY3056480 (LY-3056480)

货号: PC-26917Not For Human Use, Lab Use Only.

LY3056480 is a potent gamma secretase (γ-secretase) inhibitor (GSI), upregulates ATOH1 expression in human intestinal epithelial cell line LS174T with IC50 of 17.3 nM, inhibits Notch signalling and induces hair cell formation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LY3056480 is a potent gamma secretase (γ-secretase) inhibitor (GSI), upregulates ATOH1 expression in human intestinal epithelial cell line LS174T with IC50 of 17.3 nM, inhibits Notch signalling and induces hair cell formation.

物理化学性质&存储条件

分子量 467.49
分子式 C23H28F3N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4,4-trifluoro-N-((S)-1-(((S)-9-methoxy-3,3-dimethyl-5-oxo-2,3,5,6-tetrahydro-1H-benzo[f]pyrrolo[1,2-a]azepin-6-yl)amino)-1-oxopropan-2-yl)butanamide

参考文献

1. Anne G M Schilder, et al. Nat Commun. 2024 Mar 1;15(1):1896.

2. Silvia T Erni, et al. Front Cell Dev Biol. 2021 Aug 13:9:710159.

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