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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-MK-0752
MK-0752

Chemical Structure : MK-0752

CAS No.: 471905-41-6

MK-0752 (MK0752;MK 0752)

货号: PC-42758Not For Human Use, Lab Use Only.

MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling.

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10 mg ¥1880 In stock
25 mg ¥2880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-0752 (MK0752) is a potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells, inhibits Notch signaling.

物理化学性质&存储条件

分子量 442.9038
分子式 C21H21ClF2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-

参考文献

1. Cook JJ, et al. J Neurosci. 2010 May 12;30(19):6743-50.

2. Previs RA, et al. Clin Cancer Res. 2015 Mar 1;21(5):955-61.

3. Brana I, et al. Br J Cancer. 2014 Nov 11;111(10):1932-44.

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