RO7019009 | γ‐secretase modulator | Probechem Biochemicals

Chemical Structure : RO7019009

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RO7019009 (RO 7019009, RO-7019009)

货号: PC-24099Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

RO7019009 is a small molecule γ‐secretase modulator, efficiently reduces the levels of Aβ42 (IC50=14 nM) and Aβ40 secreted by HEK293/sw cell, effectively lowers Aβ43 of all Aβ43‐generating mutants.
RO7019009 has IC50 values for brain‐derived human neuroglioma H4 (IC50 (Aβ42) = 5 nM) or mouse neuroblastoma N2a (IC50 (Aβ42) = 2 nM) cell lines overexpressing swAPP (H4/sw, N2a/sw).
RO7019009 acts mechanistically after initial C99 binding.
RO7019009 reduces both pathogenic species and concomitantly increasing the short Aβ37 and Aβ38, of which the latter has been associated with delayed AD progression.

物理化学性质&存储条件

分子量	471.51
分子式	C22H20F3N7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Azabicyclo[3.2.1]octan-8-amine, 3-(3-methyl-1,2,4-thiadiazol-5-yl)-N-[8-(2,3,4-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-

参考文献

1. Trambauer J, et al. EMBO Rep. 2020 Jan 7;21(1):e47996.

2. Trambauer J, et al. Alzheimers Res Ther. 2025 Feb 19;17(1):49.

RO7019009 (RO 7019009, RO-7019009)

生物&药学活性

物理化学性质&存储条件

参考文献

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RO7019009 (RO 7019009, RO-7019009)

生物&药学活性

物理化学性质&存储条件

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