| Cat. No. |
Product Name |
Information |
| PC-61437 |
Vorolanib
VEGFR/PDGFR inhibitor
|
Vorolanib (CM-082) is an orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities. |
| PC-61395 |
NVP-ACC789
VEGFR-2 inhibitor
|
NVP-ACC789 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 20 nM, weakly inhibits VEGFR-1, 3 with IC50 of 180 and 380 nM. |
| PC-60958 |
PF-00337210
VEGFR-2 inhibitor
|
PF-00337210 is a potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively. |
| PC-60378 |
SU5214
VEGFR2 inhibitor
|
SU5214 is a potent VEGFR2 inhibitor extracted from patent US5834504A, has IC50s of 14.8 µM (FLK-1) and 36.7 µM (EGFR), respectively. |
| PC-70185 |
CEP-11981
VEGFR/TIE-2/FGFR1 inhibitor
|
CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM. |
| PC-60029 |
Acrizanib
VEGFR-2 inhibitor
|
Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays. |
| PC-42701 |
EG00229
VEGF-A/NRP1 inhibitor
|
EG00229 is the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1), selectively inhibits radiolabeled 125I-VEGF-A binding to PAE/NRP1 with IC50 of 8 uM. |
| PC-42637 |
Telatinib
VEGFR inhibitor
|
Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR-2 (IC50=6 nM), VEGFR-3 (IC50=4 nM), PDEGFRα (IC50=15 nM) and c-Kit (IC50=1 nM) in biochemical assays. |
| PC-42768 |
MGCD-265 analog
c-Met inhibitor
|
MGCD-265 analog is an analog of MGCD-265, and an orally bioavailable multikinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively. |
| PC-42533 |
Brivanib alaninate
VEGFR2/FGFR1 inhibitor
|
Brivanib alaninate is prodrug of Brivanib (BMS-582664), which is a dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively. |
| PC-42130 |
NVP-BAW2881
VEGFR inhibitor
|
NVP-BAW2881 is a potent, selective VEGFR inhibitor with IC50 of 37 nM for hVEGFR2 (KDR). |
| PC-42146 |
BFH772
VEGFR-2 inhibitor
|
BFH772 is a potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM. |
