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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-NVP-ACC789
NVP-ACC789

Chemical Structure : NVP-ACC789

CAS No.: 300842-64-2

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NVP-ACC789 (ZK202650, ACC789)

货号: PC-61395Not For Human Use, Lab Use Only.

NVP-ACC789 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 20 nM, weakly inhibits VEGFR-1, 3 with IC50 of 180 and 380 nM.

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10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NVP-ACC789 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 20 nM, weakly inhibits VEGFR-1, 3 with IC50 of 180 and 380 nM.
NVP-ACC789 shows no activity against FGFR-1, FGFR-3, FGFR-4, PDGFR-α, and Tie-2 tyrosine kinases at 10 uM.
NVP-ACC789 inhibits VEGF-induced cellular receptor phosphorylation with IC50 of 11.5 nM in cell-based assays, inhibits VEGF-induced HUVE cell proliferation with IC50 of 1.6 nM.

物理化学性质&存储条件

分子量 405.299
分子式 C21H17BrN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

参考文献

1. Tille JC, et al. J Pharmacol Exp Ther. 2001 Dec;299(3):1073-85.

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