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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-CEP-11981
CEP-11981

Chemical Structure : CEP-11981

CAS No.: 856691-93-5

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CEP-11981 (ESK981, CEP 11981, CEP11981)

货号: PC-70185Not For Human Use, Lab Use Only.

CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.
    CEP-11981 demonstrates a significant pre-clinical activity against human urothelial carcinoma (UC) xenografts.

    物理化学性质&存储条件

    分子量 477.56
    分子式 C28H27N7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-1,2,4,7,8,13-hexahydro-6H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6-one

    参考文献

    1. Hudkins RL, et al. J Med Chem. 2012 Jan 26;55(2):903-13.

    2. Jian W, et al. Anticancer Res. 2014 Jul;34(7):3377-82.

    3. Levitt JM, et al. J Clin Oncol. 2013 Feb 20;31(6_suppl):293.

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