EG00229 | VEGF-A/NRP1 inhibitor | Probechem Biochemicals

Chemical Structure : EG00229

CAS No.: 1210945-69-9

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EG00229 (EG 00229, EG-00229)

货号: PC-42701Not For Human Use, Lab Use Only.

EG00229 is the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1), selectively inhibits radiolabeled 125I-VEGF-A binding to PAE/NRP1 with IC50 of 8 uM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

EG00229 is the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1), selectively inhibits radiolabeled 125I-VEGF-A binding to PAE/NRP1 with IC50 of 8 uM.
EG00229 inhibits bt-VEGF-A binding to purified NRP1 b1 domain in a cell-free assay with an IC50 of 3 uM.
EG00229 shows no effect on VEGFA binding to VEGFR-1 and VEGFR-2.
EG00229 attenuates VEGFR2 phosphorylation and inhibits migration in endothelial cells.

物理化学性质&存储条件

分子量	611.595
分子式	C19H20F3N7O7S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41.4 mg/mL
Chemical Name/SMILES	L-Arginine, N2-[[3-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26.

2. Nissen JC, et al. J Neurochem. 2013 Nov;127(3):394-402.

3. Miyauchi JT, et al. Oncotarget. 2016 Mar 1;7(9):9801-14.

EG00229 (EG 00229, EG-00229)

生物&药学活性

物理化学性质&存储条件

参考文献

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EG00229 (EG 00229, EG-00229)

生物&药学活性

物理化学性质&存储条件

参考文献

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