AAD777 | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : AAD777

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AAD777 (NVP-AAD777, ZK202664)

货号: PC-61829Not For Human Use, Lab Use Only.

AAD777 (NVP-AAD777, ZK202664) is a potent, selective VEGFR-2 kinase inhibitor with IC50 of 0.65 uM, weakly inhibits VEGFR-1 and 3 with IC50 of 2.2 and 3 uM.

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生物&药学活性

AAD777 (NVP-AAD777, ZK202664) is a potent, selective VEGFR-2 kinase inhibitor with IC50 of 0.65 uM, weakly inhibits VEGFR-1 and 3 with IC50 of 2.2 and 3 uM.
AAD777 displays little or no activity against PDGFR-β tyrosine kinases, and no activity against FGFR-1, FGFR-3, FGFR-4, PDGFR-α, and Tie-2 tyrosine kinases at 10 uM.
AAD777 inhibits VEGF-induced cellular receptor phosphorylation with IC50 of 26.6 nM in cell-based assays, inhibits VEGF-induced HUVE cell proliferation with IC50 of 19.6 nM.
AAD777 enhances cigarette smoke (CS)-induced oxidative stress, causing augmented inflammatory cell influx and proinflammatory mediators release in mouse lung.

物理化学性质&存储条件

分子量	448.372
分子式	C22H14F6N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,4-bis(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

参考文献

1. Tille JC, et al. J Pharmacol Exp Ther. 2001 Dec;299(3):1073-85.

2. Edirisinghe I, et al. FASEB J. 2008 Jul;22(7):2297-310.

3. Marwick JA, et al. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L897-908.

AAD777 (NVP-AAD777, ZK202664)

生物&药学活性

物理化学性质&存储条件

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AAD777 (NVP-AAD777, ZK202664)

生物&药学活性

物理化学性质&存储条件

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