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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-Telatinib
Telatinib

Chemical Structure : Telatinib

CAS No.: 332012-40-5

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Telatinib (Bay 57-9352, Bay57-9352 )

货号: PC-42637Not For Human Use, Lab Use Only.

Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR-2 (IC50=6 nM), VEGFR-3 (IC50=4 nM), PDEGFRα (IC50=15 nM) and c-Kit (IC50=1 nM) in biochemical assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR-2 (IC50=6 nM), VEGFR-3 (IC50=4 nM), PDEGFRα (IC50=15 nM) and c-Kit (IC50=1 nM) in biochemical assays.

物理化学性质&存储条件

分子量 409.8257
分子式 C20H16ClN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

2-Pyridinecarboxamide, 4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-

参考文献

1. Steeghs N, et al. Clin Cancer Res. 2008 Jun 1;14(11):3470-6.

2. Strumberg D, et al. Br J Cancer. 2008 Nov 18;99(10):1579-85.

3. Sodani K, et al. Biochem Pharmacol. 2014 May 1;89(1):52-61.

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