PF-00337210 | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : PF-00337210

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PF-00337210 (PF 00337210, PF-210, PF-337210)

货号: PC-60958Not For Human Use, Lab Use Only.

PF-00337210 is a potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively.

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生物&药学活性

PF-00337210 is a potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively.
PF-00337210 inhibits the autophosphorylation of human and murine VEGFR-2 with IC50 of 0.87 nM and 0.83 nM, respectively.
PF-00337210 is less potent against KIT (9.6 nM), CSF1-R (13 nM), PDGFR-α (11 nM) and PDGFR-β (29 nM), and does not inhibit Flt-3 (>10 uM).
PF-00337210 shows dose-dependent anti-tumor efficacy in preclinical tumor models.

物理化学性质&存储条件

分子量	461.518
分子式	C26H27N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,2-dimethyl-6-[7-(2-morpholin-4-ylethoxy)quinolin-4-yl]oxy-1-benzofuran-3-carboxamide

参考文献

1. Bruce JY, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):527-38.

2. Tami Marrone, et al. AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

3. Majeti BK, et al. BMC Cancer. 2013 Apr 29;13:213.

PF-00337210 (PF 00337210, PF-210, PF-337210)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-00337210 (PF 00337210, PF-210, PF-337210)

生物&药学活性

物理化学性质&存储条件

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