| Cat. No. |
Product Name |
Information |
| PC-42622 |
SU14813
Multikinase inhibitor
|
SU14813 is a potent, broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS. |
| PC-27814 |
ATWLPPR peptide TFA
NRP-1 inhibitor
|
ATWLPPR peptide TFA (A7R, Ala-Thr-Trp-Leu-Pro-Pro-Arg) is a specific NRP-1 (Neuropilin 1, NRP1) inhibitor and effective antagonist of the VEGF165 binding to NRP-1 with IC50 of 5.9 uM blocks vascular endothelial growth factor (VEGF)-mediated angiogenesis. |
| PC-25873 |
Amentoflavone
VEGFR phosphorylation inhibitor
|
Amentoflavone is a naturally occurring biflavonoid with anti-inflammatory and anti-tumor properties, an antiangiogenic bioactive molecule that binds VEGFs preventing the interaction and phosphorylation of VEGF receptor 1 and 2 (VEGFR-1,VEGFR-2). |
| PC-25744 |
EG01449
NRP1 inhibitor
|
EG01449 is a specific, small molecule neuropilin-1 (NRP1) antagonist, inhibits bt-VEGFA to NRP1 b1 domain with IC50 of 362 nM, and SPR KD of 0.6 uM for binding to NRP1 b1 domain. |
| PC-25522 |
TAK-593
VEGFR2 inhibitor
|
TAK-593 is a potent, selective and ATP-competitive inhibitor of tyrosine kinases VEGFR and PDGFR with IC50s of 3.2, 0.95, 1.1, 4.3 and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα and PDFGRβ, respectively. |
| PC-25098 |
Taligantinib
Tyrosine kinase inhibitor
|
Taligantinib is a potent tyrosine kinase (such as VEGFR-2 and c-Met) inhibitor. |
| PC-24617 |
Tie2 inhibitor compound 5
Tie2 inhibitor
|
Tie2 inhibitor compound 5 (Tie2-IN-1) is a potent, selective Tie2 kinase inhibitor with IC50 of 250 nM, >200-fold selective over p38. |
| PC-23466 |
ZM-306416
VEGFR inhibitor
|
ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50 of 0.1 μM and 2 μM for KDR and Flt, respectively, also inhibits EGFR with IC50 of <10 nM. |
| PC-23424 |
MAZ51
VEGFR-3 inhibitor
|
MAZ51 is a specific inhibitor of VEGFR-3, blocks the ligand-induced autophosphorylation of VEGFR-3 and inhibits the proliferation of VEGFR-3-expressing cancer cells. |
| PC-21859 |
Axitinib
VEGFR inhibitor
|
Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. |
| PC-21310 |
NRP1-4
VEGF-A/NRP1 inhibitor
|
NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A. |
| PC-20705 |
COB223
Angiogenesis inhibitor
|
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM. |
