Tivozanib | VEGFR inhibitor | Probechem Biochemicals

Chemical Structure : Tivozanib

CAS No.: 475108-18-0

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Tivozanib (AV-951, AV951, KRN951)

货号: PC-42759Not For Human Use, Lab Use Only.

Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.

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5 mg (Free Sample)	￥280	In stock
10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
Tivozanib (AV951) also inhibits EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie2 (IC50=20-80 nM).
Tivozanib (AV951) inhibits VEGF-induced VEGFR-2 phosphorylation in endothelial cells (IC50=0.16 nM).
Tivozanib (AV951) is p.o. active.

物理化学性质&存储条件

分子量	454.8631
分子式	C22H19ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-

参考文献

1. Nakamura K, et al. Cancer Res. 2006 Sep 15;66(18):9134-42.

2. Eskens FA, et al. Clin Cancer Res. 2011 Nov 15;17(22):7156-63.

3. Momeny M, et al. Sci Rep. 2017 Apr 6;7:45954.

Tivozanib (AV-951, AV951, KRN951)

生物&药学活性

物理化学性质&存储条件

参考文献

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Tivozanib (AV-951, AV951, KRN951)

生物&药学活性

物理化学性质&存储条件

参考文献

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