EG01449 | NRP1 inhibitor | Probechem Biochemicals

Chemical Structure : EG01449

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EG01449 (EG-01449)

货号: PC-25744Not For Human Use, Lab Use Only.

EG01449 is a specific, small molecule neuropilin-1 (NRP1) antagonist, inhibits bt-VEGFA to NRP1 b1 domain with IC50 of 362 nM, and SPR KD of 0.6 uM for binding to NRP1 b1 domain.

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生物&药学活性

EG01449 is a specific, small molecule neuropilin-1 (NRP1) antagonist, inhibits bt-VEGFA to NRP1 b1 domain with IC50 of 362 nM, and SPR KD of 0.6 uM for binding to NRP1 b1 domain.
EG01449 (30 uM) inhibits VEGFA-induced permeability and signaling in models-vascular endothelial cells of the ex vivo mouse retina and human brain endothelial cells.
EG01449 (30 uM) prevents VEGFA-induced p38 phosphorylation in human brain endothelial cell line hCMEC/D3.
EG01449 (30 uM) significantly reduced VEGFA-induced dye extravasation in mouse brain and retinae.
EG01449 (30 uM) prevented the VEGFA-mediated increase in total sodium currents in DRG neurons.
EG01449 reduces VEGFA induced pain-like phenotype in male and female rats, blocks VEGFA-induced increase in aversion to mechanical stimuli in rats.
EG01449 does not activate p38 mitogen-activated protein kinase and exhibited a purely inhibitory pharmacological profile.

物理化学性质&存储条件

分子量	686.83
分子式	C28H34N10O5S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((6-(((2-(piperazin-1-yl)thiazol-4-yl)methyl)amino)quinoline)-8-sulfonamido)thiophene-2-carbonyl)-L-arginine

参考文献

1. Hestehave S, et al. ACS Pharmacol Transl Sci. 2025 Oct 29;8(11):3844-3871.

EG01449 (EG-01449)

生物&药学活性

物理化学性质&存储条件

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EG01449 (EG-01449)

生物&药学活性

物理化学性质&存储条件

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