ATWLPPR peptide TFA

Chemical Structure : ATWLPPR peptide TFA

CAS No.:

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货号: PC-27814Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ATWLPPR peptide TFA (A7R, Ala-Thr-Trp-Leu-Pro-Pro-Arg) is a specific NRP-1 (Neuropilin 1, NRP1) inhibitor and effective antagonist of the VEGF165 binding to NRP-1 with IC50 of 5.9 uM blocks vascular endothelial growth factor (VEGF)-mediated angiogenesis.
ATWLPPR completely abolished VEGF binding to cell-displayed kinase domain receptor (KDR/FLK1 or VEGFR-2).
ATWLPPR inhibits VEGF-mediated proliferation of human vascular endothelial cells, in a dose-dependent and endothelial cell type-specific manner.
ATWLPPR totally abolishes VEGF-induced angiogenesis in a rabbit corneal model.

物理化学性质&存储条件

分子量	954.00
分子式	C42H62F3N11O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ala-Thr-Trp-Leu-Pro-Pro-Arg TFA salt

参考文献

1. Binétruy-Tournaire R, et al. EMBO J. 2000 Apr 3;19(7):1525-33.

2. Rodrigues S, et al. FASEB J. 2003 Jan;17(1):7-16.

3. Tymecka D, et al. Eur J Med Chem. 2018 Oct 5;158:453-462.

4. Starzec A, et al. Peptides. 2007 Dec;28(12):2397-402.