SU14813 |CAS 627908-92-3 Probechem Biochemicals

Chemical Structure : SU14813

CAS No.: 627908-92-3

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SU14813 (SU-14813, SU 14813)

货号: PC-42622Not For Human Use, Lab Use Only.

SU14813 is a potent, broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS.

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5 mg	￥380	In stock
10 mg	￥580	In stock
25 mg	￥980	In stock
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生物&药学活性

SU14813 is a potent, broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS.
SU14813 shows poor activity for EGFR and c-Met in biochemical assays.
SU14813 inhibits VEGFR-2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells with IC50 of 5.2, 9.9, and 11.2 nM respectively.
SU14813 is active in xenograft tumor models.

物理化学性质&存储条件

分子量	442.4833
分子式	C23H27FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-3-carboxamide, 5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-

参考文献

1. Patyna S, et al. Mol Cancer Ther. 2006 Jul;5(7):1774-82.

2. Hu-Lowe D, et al. Mol Cancer Ther. 2011 Nov;10(11):2015.

SU14813 (SU-14813, SU 14813)

生物&药学活性

物理化学性质&存储条件

参考文献

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SU14813 (SU-14813, SU 14813)

生物&药学活性

物理化学性质&存储条件

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