| Cat. No. |
Product Name |
Information |
| PC-45746 |
Fruquintinib
VEGFR inhibitor
|
Fruquintinib (HMPL-013) is a potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively. |
| PC-42762 |
Lenvatinib
VEGFR inhibitor
|
Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays. |
| PC-42450 |
Cediranib
VEGFR inhibitor
|
Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively. |
| PC-42759 |
Tivozanib
VEGFR inhibitor
|
Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3. |
| PC-42534 |
Brivanib (BMS540215)
VEGFR2/FGFR1 inhibitor
|
Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively. |
| PC-42623 |
SU14813 maleate
Multikinase inhibitor
|
SU14813 maleate is a broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS. |
| PC-42622 |
SU14813
Multikinase inhibitor
|
SU14813 is a potent, broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS. |
| PC-23466 |
ZM-306416
VEGFR inhibitor
|
ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50 of 0.1 μM and 2 μM for KDR and Flt, respectively, also inhibits EGFR with IC50 of <10 nM. |
| PC-23424 |
MAZ51
VEGFR-3 inhibitor
|
MAZ51 is a specific inhibitor of VEGFR-3, blocks the ligand-induced autophosphorylation of VEGFR-3 and inhibits the proliferation of VEGFR-3-expressing cancer cells. |
| PC-22874 |
TU2218
ALK5/VEGFR2 inhibitor
|
TU2218 is a small-molecule inhibitor that inhibits dual ALK5/VEGFR2 with IC50 of 1.2 nM and 4.5 nM respectively. |
| PC-21859 |
Axitinib
VEGFR inhibitor
|
Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. |
| PC-21447 |
NRPa-308
NRP1 inhibitor
|
NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity. |
