Fruquintinib (HMPL-013) | VEGFR inhibitor | Probechem Biochemicals

Chemical Structure : Fruquintinib

CAS No.: 1194506-26-7

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Fruquintinib (HMPL-013, HMPL013)

货号: PC-45746Not For Human Use, Lab Use Only.

Fruquintinib (HMPL-013) is a potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1580	In stock
50 mg	￥2380	In stock
100 mg	￥3280	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Fruquintinib (HMPL-013) is a potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively.
Fruquintinib (HMPL-013) weakly inhibits RET, FGFR-1 and c-kit kinases.
Fruquintinib (HMPL-013) demonstrates potent inhibition on VEGF-A dependent KDR phosphorylation in HEK293-KDR cells and VEGF-A induced proliferation in primary HUVECs with IC50 of 0.6 nM and 1.7 nM, respectively.
Fruquintinib (HMPL-013) suppresses tumor growth inhibition in a panel of tumor xenograft and patient derive xenograft models in mouse.
Fruquintinib (HMPL-013) is orally active.

物理化学性质&存储条件

分子量	393.3927
分子式	C21H19N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 7.75 mg/mL
Chemical Name/SMILES	3-Benzofurancarboxamide, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-

参考文献

1. Sun Q, et al. Cancer Biol Ther. 2014;15(12):1635-45.

2. Gu Y, et al. Cancer Chemother Pharmacol. 2014 Jul;74(1):95-115.

3. Cao J, et al. Cancer Chemother Pharmacol. 2016 Aug;78(2):259-69.

Fruquintinib (HMPL-013, HMPL013)

生物&药学活性

物理化学性质&存储条件

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Fruquintinib (HMPL-013, HMPL013)

生物&药学活性

物理化学性质&存储条件

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