Cediranib |CAS:288383-20-0 Probechem Biochemicals

Chemical Structure : Cediranib

CAS No.: 288383-20-0

加入收藏

Cediranib (AZD2171;AZD 2171;AZD-2171)

货号: PC-42450Not For Human Use, Lab Use Only.

Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.

规格	价格	库存
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.
Cediranib (AZD2171) also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR.
Cediranib (AZD2171) inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells.
Cediranib (AZD2171) inhibits angiogenesis, neovascular survival and tumor growth in vivo.

物理化学性质&存储条件

分子量	450.5053
分子式	C25H27FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 49 mg/mL
Chemical Name/SMILES	Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-

参考文献

1. Wedge SR, et al. Cancer Res. 2005 May 15;65(10):4389-400.

2. Denduluri N, et al. Clin Breast Cancer. 2005 Dec;6(5):460-3.

3. Batchelor TT, et al. Cancer Cell. 2007 Jan;11(1):83-95.

4. Cao C, et al. Cancer Res. 2006 Dec 1;66(23):11409-15.

Cediranib (AZD2171;AZD 2171;AZD-2171)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Cediranib (AZD2171;AZD 2171;AZD-2171)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.