Cediranib maleate |CAS:857036-77-2 Probechem Biochemicals

Chemical Structure : Cediranib maleate

CAS No.: 857036-77-2

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Cediranib maleate (AZD-2171 maleate;AZD 2171 maleate)

货号: PC-43353Not For Human Use, Lab Use Only.

A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.

规格	价格	库存
10 mg	￥720	In stock
50 mg	￥2640	In stock
100 mg	￥3680	In stock

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生物&药学活性

A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively; also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR; inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells; inhibits angiogenesis, neovascular survival and tumor growth in vivo.

Ovarian Cancer

Phase 3 Clinical

物理化学性质&存储条件

分子量	566.5775
分子式	C29H31FN4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-, (2Z)-2-butenedioate (1:1)

参考文献

1. Wedge SR, et al. Cancer Res. 2005 May 15;65(10):4389-400.

2. Denduluri N, et al. Clin Breast Cancer. 2005 Dec;6(5):460-3.

3. Batchelor TT, et al. Cancer Cell. 2007 Jan;11(1):83-95.

4. Cao C, et al. Cancer Res. 2006 Dec 1;66(23):11409-15.

Cediranib maleate (AZD-2171 maleate;AZD 2171 maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Cediranib maleate (AZD-2171 maleate;AZD 2171 maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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