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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-Vandetanib
Vandetanib

Chemical Structure : Vandetanib

CAS No.: 443913-73-3

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Vandetanib (ZD6474;ZD-6474;ZD 6474)

货号: PC-42496Not For Human Use, Lab Use Only.

Vandetanib (ZD6474) is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.

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50 mg ￥1180 In stock
100 mg ￥1780 In stock
200 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vandetanib (ZD6474) is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
Vandetanib (ZD6474) shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively).
Vandetanib (ZD6474) displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM).
Vandetanib (ZD6474) has excellent solubility and good oral bioavailability.

物理化学性质&存储条件

分子量 475.354
分子式 C22H24BrFN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 27.5 mg/mL
Chemical Name/SMILES

4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-

参考文献

1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.

2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.

3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.

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