Vandetanib hydrochloride |CAS:524722-52-9 Probechem Biochemicals

Chemical Structure : Vandetanib hydrochloride

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Vandetanib hydrochloride (ZD6474 hydrochloride;ZD-6474 hydrochloride;ZD 6474 hydrochloride)

货号: PC-42498Not For Human Use, Lab Use Only.

Vandetanib hydrochloride is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Vandetanib hydrochloride is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
Vandetanib shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively).
Vandetanib displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM).
Vandetanib has excellent solubility and good oral bioavailability.

物理化学性质&存储条件

分子量	511.8149
分子式	C22H25BrClFN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-, hydrochloride (1:1)

参考文献

1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.

2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.

3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.

Vandetanib hydrochloride (ZD6474 hydrochloride;ZD-6474 hydrochloride;ZD 6474 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Vandetanib hydrochloride (ZD6474 hydrochloride;ZD-6474 hydrochloride;ZD 6474 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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