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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-Axitinib
Axitinib

Chemical Structure : Axitinib

CAS No.: 319460-85-0

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Axitinib (AG-013736, AG013736)

货号: PC-21859Not For Human Use, Lab Use Only.

Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

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500 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

物理化学性质&存储条件

分子量 386.47
分子式 C22H18N4OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

参考文献

1. Fenton BM, et al. Cancer Res. 2007 Oct 15;67(20):9921-8.

2. Hu-Lowe DD, et al. Clin Cancer Res. 2008 Nov 15;14(22):7272-83.

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