Acrizanib | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : Acrizanib

CAS No.: 1229453-99-9

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Acrizanib (LHA510, LHA-510)

货号: PC-60029Not For Human Use, Lab Use Only.

Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays.

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5 mg	￥2380	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays.
Acrizanib (LHA510) exhibits <10% remaining kinase activity against only 13 wildtype kinases, CSF1R, Kit, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, VEGFR3, Fms, DDR1, DDR2, TIE1, and ABL1 in a panel of >400 kinases.
Acrizanib (LHA510) demonstrates potency and efficacy in rodent CNV models, limited systemic exposure after topical ocular administration, multiple formulation options, and an acceptable rabbit ocular PK profile.

物理化学性质&存储条件

分子量	445.406
分子式	C20H18F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-({6-[(methylamino)methyl]pyrimidin-4-yl}oxy)-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-1H-indole-1-carboxamide

参考文献

1. Adams CM, et al. J Med Chem. 2018 Feb 5. doi: 10.1021/acs.jmedchem.7b01731.

Acrizanib (LHA510, LHA-510)

生物&药学活性

物理化学性质&存储条件

参考文献

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Acrizanib (LHA510, LHA-510)

生物&药学活性

物理化学性质&存储条件

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