YM-359445 | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : YM-359445

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YM-359445 (YM359445)

货号: PC-61439Not For Human Use, Lab Use Only.

YM-359445 (YM359445) is a highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM).

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生物&药学活性

YM-359445 (YM359445) is a highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM).
YM-359445 inhibits VEGFR2 tyrosine kinase activity completely at 0.03 uM, inhibits HUVEC proliferation induced by VEGF with IC50 of 1.5 nM.
YM-359445 inhibits VEGF-stimulated autophosphorylation of VEGFR2 at 0.1 nM, also inhibits sprout formation of endothelial cells at 3 nM.
YM-359445 not only inhibits tumor growth but also reduces its vasculature in mice bearing various tumors, including paclitaxel-resistant tumors.

物理化学性质&存储条件

分子量	662.718
分子式	C32H34N6O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3Z)-3-[6-[(4-methylpiperazin-1-yl)methyl]quinolin-2(1H)-ylidene]-2-oxoindoline-6-carbaldehyde O-(1,3-thiazol-4-ylmethyl)oxime mono-l-tartrate

参考文献

1. Amino N, et al. Clin Cancer Res. 2006 Mar 1;12(5):1630-8.

YM-359445 (YM359445)

生物&药学活性

物理化学性质&存储条件

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YM-359445 (YM359445)

生物&药学活性

物理化学性质&存储条件

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