PAN-90806 | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : PAN-90806

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PAN-90806 (CP-547632, CP547632, PAN90806)

货号: PC-61438Not For Human Use, Lab Use Only.

PAN-90806 (CP-547632, CP547632) is a highly potent, ATP-competitive, orally active VEGFR-2 inhibitor that blocks VEGFR-2 kinase autophosphorylation (IC50=11 nM) and VEGF-induced VEGFR-2 phosphorylation (IC50=5 nM).

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

PAN-90806 (CP-547632, CP547632) is a highly potent, ATP-competitive, orally active VEGFR-2 inhibitor that blocks VEGFR-2 kinase autophosphorylation (IC50=11 nM) and VEGF-induced VEGFR-2 phosphorylation (IC50=5 nM).
PAN-90806 is approximately equipotent (<10-fold) against VEGFR-2, bFGF receptor and EGFR/Tie-2 chimera, 250-1000-fold selectivity over PDGFRβ, EGFR and InsR.
PAN-90806 inhibits tumor-associated VEGFR-2 phosphorylation with decreased microvascular density and significant tumor growth inhibition in a number of tumor models.

物理化学性质&存储条件

分子量	532.4
分子式	C20H24BrF2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide

参考文献

1. Beebe JS, et al. Cancer Res. 2003 Nov 1;63(21):7301-9.

2. Cohen RB, et al. Cancer Chemother Pharmacol. 2007 Jun;60(1):81-9.

PAN-90806 (CP-547632, CP547632, PAN90806)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PAN-90806 (CP-547632, CP547632, PAN90806)

生物&药学活性

物理化学性质&存储条件

参考文献

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