| Cat. No. |
Product Name |
Information |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-24267 |
SOF-436
Ras inhibitor
|
SOF-436 is a small molecule covalent KRAS inhibitor with IC50 of 60 uM in nucleotide exchange assays, inhibits KRAS nucleotide exchange by guanine exchange factor SOS1 and the binding of KRAS to effector protein RAF. |
| PC-24256 |
(RS)-G12Di-1
KRAS-G12D inhibitor
|
(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D. |
| PC-24200 |
Zoldonrasib
KRAS inhibitor
|
Zoldonrasib is a potent, selective peptide-linked macrocyclic dipeptidic inhibitor of KRas. |
| PC-24185 |
Sosimerasib
Ras inhibitor
|
Sosimerasib is a potent, selective inhibitor of KRAS. |
| PC-24126 |
D3S-001
KRAS G12C inhibitor
|
Elisrasib (D3S-001) is a potent, selective, CNS-penetrable, covalent inhibitor of GDP-bound KRAS G12C inhibitor, decreases cellular active KRAS proteins in a dose-dependent manner (IC50=0.6 nM) in NCI-H358 cells. |
| PC-23931 |
ISM061-022
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor with IC50 values in the micromolar range, shows selectivity toward certain KRAS mutants. |
| PC-23930 |
ISM061-018-2
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants. |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
