KBFM123 |CAS:1090346-46-5 Probechem Biochemicals

Chemical Structure : KBFM123

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KBFM123 (KBFM-123)

货号: PC-35613Not For Human Use, Lab Use Only.

KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM).

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生物&药学活性

KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM).
KBFM123 interacts directly with a hydrophobic pocket located between Switch I and Switch II and allosterically inhibits the effector interaction by inducing conformational changes in Switch I and its flanking region in the β2-strand, which are directly involved in recognition of the effector molecules including c-Raf-1.
KBFM123 is a promising scaffold for the development of Ras inhibitors.

物理化学性质&存储条件

分子量	271.316
分子式	C16H17NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-hydroxy-N-((tetrahydrofuran-2-yl)methyl)-2-naphthamide

参考文献

1. Matsumoto S, et al. Biochemistry. 2018 Aug 24. doi: 10.1021/acs.biochem.8b00680.

KBFM123 (KBFM-123)

生物&药学活性

物理化学性质&存储条件

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KBFM123 (KBFM-123)

生物&药学活性

物理化学性质&存储条件

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