| Cat. No. |
Product Name |
Information |
| PC-35587 |
RAS inhibitor Abd-7
RAS inhibitor
|
RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling. |
| PC-35391 |
SOS1 activator 17
SOS1 activator
|
SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro. |
| PC-35300 |
RasGRP3 ligand 96
RasGRP3 ligand
|
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively. |
| PC-63506 |
CMC2.24
Ras inhibitor
|
CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo. |
| PC-43022 |
6H05 trifluoroacetate
KRAS G12C inhibitor
|
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C), an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.. |
| PC-43021 |
6H05
KRAS G12C inhibitor
|
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C), an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.. |
| PC-62695 |
pan-Ras inhibitor 3144
Ras inhibitor
|
pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively. |
| PC-62496 |
ARS-1323
KRAS G12C inhibitor
|
ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853.. |
| PC-62495 |
ARS-1630
|
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
| PC-62494 |
ARS-1620
KRAS G12C inhibitor
|
ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with an observed rate of 1,100±200 M-1S-1, shows >10-fold improved potency over the initial ARS-853. |
| PC-62490 |
NSC 658497
SOS1 inhibitor
|
NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. |
| PC-62207 |
SCH 54292
Ras-GEF inhibitor
|
SCH 54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 uM. |
