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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-KRA-533
KRA-533

Chemical Structure : KRA-533

CAS No.: 10161-87-2

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KRA-533 (NSC112533, KRA533)

货号: PC-72963Not For Human Use, Lab Use Only.

KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS.
KRA-533 activates KRAS in association with growth inhibition of NSCLC cells, directly binds and activates WT and mutant KRAS (G12C, G12D and G13D mutant) in an in vitro cell-free system.
KRA-533 activated exogenous WT and S17A but not K117A KRAS mutant in A549 cells, suggest that the Lys117 hydrogen-bond site is required for KRA-533 to bind or activate KRAS.
KRA-533 induces KRAS activation leading to apoptotic and autophagic cell death in human lung cancer cells.
KRA-533 suppresses mutant KRAS lung cancer in xenograft models.

物理化学性质&存储条件

分子量 314.179
分子式 C13H16BrNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-(2-bromoacetamido)butyl)benzoic acid

参考文献

1. Ke Xu, et al. Mol Cancer. 2019; 18: 85.

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