| Cat. No. |
Product Name |
Information |
| PC-73323 |
GDC-6036
KRAS G12C inhibitor
|
GDC-6036 (Divarasib, RG6330) is a potent, selective, covalent and orally available KRAS G12C inhibitor with HTRF IC50 of 2.9 pM. |
| PC-73313 |
MRTX0902
SOS1 inhibitor
|
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK). |
| PC-73069 |
Sotorasib racemate
KRAS G12C inhibitor
|
Sotorasib (AMG510) racemate is an orally active racemate of Sotorasib (AMG510), a potent, selective, covalent KRAS G12C inhibitor. |
| PC-73005 |
TH-Z835
KRAS G12D inhibitor
|
TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM. |
| PC-72978 |
PHT-7.3
Cnksr1 (Cnk1) inhibitor
|
PHT-7.3 (Cnksr1 (Cnk1) inhibitor PHT-7.3) is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). |
| PC-72963 |
KRA-533
KRAS agonist
|
KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS. |
| PC-72958 |
ASP2453
KRAS G12C inhibitor
|
ASP2453 (ASP-2453) is a novel potent, selective and covalent KRAS G12C inhibitor, inhibits SOS-mediated interaction between KRAS G12C and Raf with IC50 of 40 nM. |
| PC-72897 |
JDQ443
KRAS G12C inhibitor
|
JDQ443 (Opnurasib, NVP-JDQ443) is a potent, mutant-selective, covalent KRAS G12C inhibitor. |
| PC-72832 |
NSC290956
Kras inhibitor
|
NSC290956 (Spiclomazine, Clospirazine) is a small molecule inhibitor of KRas with Kd of 21.3 uM. |
| PC-72332 |
BI-2852
KRAS inhibitor
|
BI-2852 (BI 2852) is a potent pan-Ras inhibitor, targets GTP-bound KRAS, binds to KRASG12D with a KD of 740 nM (ITC), inhibits GTP-KRAS G12D binding to effectors like SOS1, CRAF and PI3Kα with an IC50 of 490, 770 and 500 nM. |
| PC-72331 |
MRTX1133
KRAS G12D inhibitor
|
MRTX-1133 (MRTX1133) is a potent, selective and noncovalent inhibitor KRAS G12D with SPR Kd of 0.2 nM, AlphaLISA IC50 of 5 nM. |
| PC-72314 |
KRAS G12C Pipetide LVVVGACGVGK
|
KRAS G12C Pipetide (LVVVGACGVGK) is a KRas4B G12C allele-specific N-terminal mutant tryptic peptide. |
